Many organizations are moving towards sustainability in the supply chain and the implementation of this combination in supply chain management has become a critical issue for organizations. Sustainability refers to the appropriate balance between economic development, environmental monitoring and social assets, and each of the businesses that make up the supply chain must have sustainable performance, according to the standard indicators of sustainability. Considering the importance of the rubber industry in the economic development of the country, it is necessary to implement such a chain in this industry. The purpose of this research is to design a sustainable supply chain model with an economic approach in the rubber industry. For this purpose, at first, by reviewing the literature and research history, the factors affecting the sustainability of the supply chain were identified with an economic approach. In the next step, using the statistical hypothesis test, the effectiveness of these supply chain stability factors in the rubber industry was investigated. For this purpose, based on the literature review, eight hypotheses were developed and evaluated by distributing questions and all of them were found to be effective. Then, using interpretive structural modeling technique, the variables were structured in the form of a schematic model. Based on this model, the factors of "financial components", "research and development" and "information technology" were the basic variables that should be given more attention in order to achieve a sustainable supply chain with an economic approach.